This blog post is based on a conversation between me (Suzanne Elvidge, freelance writer and journalist at Peak Words) and the #CoffeeBuddies, a virtual discussion group hosted by Graham Combe and chaired by Professor Tony Sedgwick. Book to join #CoffeeBuddies on Tuesdays and Thursdays at 2.30 pm BST (GMT+1 hr) at Eventbrite.
 
News outlets, including print and online media, have not had a good reputation for reporting breakthroughs in science and medicine:

• Beer is better than paracetamol for pain relief
• Eggs cause ovarian cancer
• Nutella causes cancer
• Phone masts are linked to suicides
• An injection can cut your weight in days

This can be as a result of ignorance or intentional twisting of the truth, but it can also be as a result of either poor communication of the science to the press, or communication of poor science. To help readers, here's a rough guide to spotting bad science in the media.

Why it's important to get science into the media
There are two key audiences for science and research in news media; the general population, and pharma industry personnel.

Unless they have a particular interest in science, lay people are often looking to find out how breakthroughs in science and medicine will affect their health and that of their families or friends. News in the mainstream media, in print or online is a way to educate people about the scientific process, how research really works, and how long drug development actually takes. And this has never been more important than during the Covid-19 pandemic.

Business development teams and management at C-suite level in the biopharma industry use the media, including specialist news publications and sites, and trade publications, to find out about new approaches, breakthroughs, technologies and techniques, and find collaborators. Investors use similar sources to see who needs funding and who could provide a return on investment.

Talking to the press
Good media coverage of research does depend on how the science is communicated by the scientists – it is the responsibility of both the scientist and the journalist. This means the interaction between the scientist and the journalist is very important.

Start by knowing both of the audiences – the journalist's level of knowledge, and the readers' knowledge and needs. Not all news stories are written by science writers, and not all science or health writers have a science background. Conversations and press releases need to be in the right language for the audience, in plain English without hyperbole, and without too much 'science speak' for a non-science audience.

It's important for scientists to speak on a level that people can understand - using jargon or high science terms can make the conversation complex and isn't worthwhile for the reporter or their audience – Lisa LaMotta, Editor-in-Chief, Risk & Regulatory Thought Leadership at PwC.

Journalists are busy people – those who are working for online daily news publications may be putting out anything from three to five or more stories a day. A good press release will increase the chance of getting a story noticed and published. Presented with a pitch or press release, the journalist will pick the one that is well written, contains good information, answers the right questions and includes feasible quotes over and above the one that is just PR fluff and insubstantial, generic quotes. Don't keep on calling journalists to see if they have received your press release, unless there is a good chance that it has gone astray, or there is something useful to add.

Hints and tips for a good release:

• Make sure it’s not just advertising dressed up as a story, and don’t overstate things
• State facts; don’t be vague
• Keep it brief
• Keep in mind what you would want to read in a news story
  • Think about what, where, when, who, why, how – and so what
• If you include contacts, check their availability
• Pictures add impact, and case studies provide a human face
  • But remember the audience and match the pictures to the publication
• Background information is helpful – the company, the technology, the disease, the drug, and independent information sources
• Quotes are important – but keep them realistic and snappy

And a bit of advice talking to the press:

• Prepare well, and practice if it makes you feel more confident
• Listen carefully to questions, and answer the questions the journalist asks, not the questions you want to answer
• Know what you can and can’t say
• Remember your audience and use the right language

How the media publishes science: the anatomy of a story
Tracking a piece of science research gives an idea of how different outlets report science, and where they get their information.

The original paper
The original paper, 'Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer', was published in The Lancet Oncology. This paper compared vascular-targeted photodynamic therapy, derived from a sea-dwelling bacterium, with standard-of-care (watchful waiting) in men with low-risk prostate cancer and suggested that it was safe and effective and could defer or avoid more radical therapy.

The press release
The press release, entitled ' Light therapy effectively treats early prostate cancer', came from University College London. It's written in user-friendly language, and its statements and conclusions are much more definitive than those in the original paper. It also provides an image and some links.

Medical press
The pieces in the Urology Times and Cancer Therapy Advisor both target physicians. They both use non-sensational language, and their conclusions are cautious, couched in a scientific and medical perspective. The key differences are that the Urology Times uses the press release as the source, including quotes, whereas the Prostate Cancer Advisor relies more on the original paper. To provide validation, the Prostate Cancer Advisor includes a perspective from a physician not included in the study.

Popular science press
IFL Science's approach to the story uses lay language but does not dumb down the story, and also uses some information from the press release to shape the piece. It pulls in background information to expand on the topic. Importantly, it says that the drug is not yet approved – this is from the press release and is vital in managing readers' expectations. The conclusion is positive, but the language remains measured

The newspapers
Newspaper coverage of science can be sensationalist, including titles with phrases such as: 'Researchers were shocked by results', 'Miracle drug', 'Results are astonishing', 'Blockbuster' or 'Cure'. The Telegraph's piece (now behind a paywall) emphasises 'complete remission for half of patients' in the title. The Daily Mail, a newspaper fond of capital letters, says that the 'bacteria… will kill prostate cancer in HALF of all patients'. The Sun (a paper with a strong male readership) highlights in its title that the treatment won't leave men impotent. Both The Sun and The Telegraph mention that the treatment isn't approved yet. As many newspaper stories leave people clamouring for a treatment that may be years away from approval, this confirms how important it is to include these details in the press release.

The story in all three newspapers is shaped very strongly by the press release. Each article has pulled in information from UK cancer charities to provide additional information for the readers; this also provides validation for the piece.
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Learnings from the analysis

• The press release can drive the shape of the story
• For science and technical reporters, access to the paper is important
• For more mainstream reporting, the press release is the key source
• For products, giving timelines can help to manage expectations, especially for early stage science

A preprint of a study released earlier this week has confirmed the increased risk of hospital death in people of south Asian backgrounds with Covid-19, and has started a look into the reasons why. 




Since the early days of the Covid-19 outbreak, there have been reports of higher levels of deaths in people of colour. A Public Health England report looked into the links between ethnicity and outcomes of Covid-19, and showed that the risk of death is higher in people from black and Asian ethnic groups compared with white people.
 
The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients looked at data from 30,693 people admitted to 260 hospitals in England, Scotland and Wales between February and May 2020. There was no difference in severity of illness on admission. While just 5% of the people admitted had ethnicity reported as south Asian, people from this cohort were 19% more likely to die than white patients. People from all ethnic minorities were also more likely to need intensive care.

The increased rate of diabetes in the south Asian patient cohort compared with the white patients (40% vs 25%) could explain (at least in part) the increased risk of death. Type 2 diabetes has links with increased risk of death in hospital in people with Covid-19. In May 2020, an NHS England report showed that of the 23,804 people who had died in hospital as a result of a coronavirus infection, almost a third had a diagnosis of type 2 diabetes. When in hospital with Covid-19, people with type 2 diabetes are twice as likely to die than people who don't have diabetes.

The implications of the ISARIC CCP-UK study, as discussed by the authors, are that ethnicity should be accounted for in decisions about prevention, treatment and vaccination, and any disease-related guidance and policies should be developed with an awareness of the high percentage of south Asians in public-facing and key worker roles. 

This blog post is based on a conversation between Ian Rees, Unit Manager Inspectorate Strategy and Innovation at the MHRA and the #CoffeeBuddies, a virtual discussion group hosted by Graham Combe and chaired by Professor Tony Sedgwick. Book to join #CoffeeBuddies on Tuesdays and Thursdays at 2.30 pm BST (GMT+1 hr) at Eventbrite.

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The core principle of the Medicines & Healthcare products Regulatory Agency (MHRA) is to ensure that medicines, medical devices and blood components for transfusion are safe, of an appropriate quality, effective, and can be manufactured consistently.
The MHRA is made up of three centres:

• Clinical Practice Research Datalink (CPRD)
  • A data research service that aims to improve public health by using anonymised NHS clinical data
• National Institute for Biological Standards and Control (NIBSC)
  • Carries out basic research and is responsible for the standardisation and control of biological medicines
• MHRA
  • Regulator for medicines, medical devices and blood components for transfusion in the UK, ensuring their safety, quality and effectiveness, and enforcing inspections

 
The MHRA needs to do what is appropriate with each individual project, and to achieve this, works in collaboration with a range of organisations along the development pathway to create as integrated a programme as possible:

• UK Research and Innovation (UKRI)
• Innovate UK
• National Institute for Health Research (NIHR)
• The Catapult Network
• National Institute for Health and Care Excellence (NICE)
• Accelerated Access Collaborative (AAC)
• NHS

 
From an international perspective, the MHRA also works with:

• Pharmaceutical Inspection Co-operation Scheme (PIC/S)
• International Coalition of Medicines Regulatory Authorities (ICMRA)
• International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH)
• National pharmacopeias
• National enforcement agencies

 
Supporting innovation
The MHRA provides advice at any stage of development across the whole of the drug development lifecycle, and according to Rees, the earlier the developers request the advice, the better. The MHRA innovation office works with companies, research institutions, consortia and hospitals as they make the step from the bench to the bedside (the discovery and preclinical steps in translational medicine). This support includes innovations in drug and device development and in manufacturing processes. The innovation office also carries out horizon-scanning activities, keeping the MHRA as a whole up-to-date on emerging technologies, medicines and devices. The inspection and assessments office then covers the stages from preclinical to market.
 
One of the important roles of the innovation office is to provide confidential and informal expert regulatory information, advice and guidance, allowing inventors to begin to access the inspection pathway and engagement process. This free advice leads into the more formal scientific advice meetings and interim inspections. The MHRA also works with NICE to provide joint scientific advice to create clinical trials that could support and even accelerate adoption.
 
Companies and institutions developing innovative medicines for life threatening or seriously debilitating conditions with clear unmet medical need may also be able to access the early access to medicines scheme (EAMS). This allows patients to access drugs before marketing authorisation.
The innovation office was launched in 2013, and since then has dealt with more than a thousand enquiries and facilitated over 150 meetings. However, these have mostly been with research institutions and small and medium enterprises (SMEs); big pharma companies seem to be less interested in discussion. This can lead to delays – for example, a big pharma company wanted to move from batch to continuous manufacturing, but it took almost two years for the company to release a polished version of the documentation to the MHRA. Had this been provided at an earlier stage, the 'polishing' could have been carried out in parallel with the discussions, meaning the manufacturing could have begun up to 18 months earlier.
 
The impact of Covid-19
The coronavirus pandemic and the drive for new vaccines, therapeutics and diagnostics is changing perceptions of what is possible in data gathering and product approval. The push to move products into clinical trials quickly has compelled developers and regulators to discuss projects and seek scientific advice. The MHRA is able to prioritise and support Covid-19 research, and has procedures in place for rapid scientific advice, reviews and approval. Examples of projects that have been able to move faster under the pandemic conditions include the convalescent plasma programme, the approval of the use of remdesevir in certain patient populations under EAMS, and the approval of the Covid-19 Oxford Vaccine Trial in seven working days.
 
MHRA post-Brexit
The shape of the existing UK regulatory pathways won't change in a post-Brexit world, but what is not yet clear is whether regulatory approvals will remain linked with EMA, or the MHRA will act as a standalone regulator. The MHRA's guidance updated in February 2020 states that the UK can only act as a concerned member state (CMS) in decentralised procedures or mutual recognition procedures until the end of the transition period. There is still so much uncertainty at the moment, but the aim post-Brexit is for a better-integrated pathway that brings in other agencies in parallel.
 
It is possible that the MHRA could reduce in importance compared with the Asian and US regulatory agencies, as the UK is no longer the gateway to Europe. However, working in partnership with individual or groups of regulatory authorities could make the MHRA work faster, and be more responsive, innovative and flexible. This would require managing the balance between science and risk. 

In discussions about ethical and moral issues, the world is full of opposing viewpoints, never more so than in the midst of the coronavirus pandemic and the aftermath of the George Floyd killing.

The best and most fruitful discussions are based around respectful disagreement, which seeks to understand why someone thinks how they do and prioritises logic and facts over opinion in the response. Building a consensus framework for medical ethics, particularly in troubled times, needs this kind of reasoned respectful disagreement.

Medical ethics isn't always about consensus though. It can be about a single voice speaking up against the status quo.  The issues and skills learned and discussed in medical ethics are not just relevant in healthcare they are widely applicable anywhere.
 
Ethics: the personal perspective
Our personal ethics can be driven by our goals, beliefs and values, and by the conditions in which we find ourselves, and all of these can influence communication and clinical practice.

• Goals – can be wide-ranging, from helping people through healthcare, through a job well-done, to money and status. The importance of these can vary throughout our careers, and the urge to reach them can distort our approaches, for example by falsifying data.
• Beliefs – we all have different sets of beliefs, depending on how we were brought up, what religious or spiritual beliefs we do (or don't) have, or where our politics lie on a broad spectrum. These can change how we interpret data, or the conclusions we reach.
• Values – we have different ways of assigning good and doing right, whether it's about maximising happiness, recognising intrinsic worth, or providing choice.
• Conditions – are we hungry, angry, late or tired (HALT)? Are we rich or poor, junior or senior?

Ethics: Coming to consensus
When people understand why they are doing something, and are supplied with principles, structures and processes, they are more likely to comply. Medical ethics frameworks, created through discussion and consensus, should therefore include:

• Guidelines for behaviour (principles)
• Established forms of knowledge and patterns of behaviour (structures)
• How things are done (processes)

The framework should be applicable to healthcare professionals across the range of professions and agencies, but it should consider different people and perspectives. If guidelines are created for individual groups, care needs to be taken where the sets of people cross over, for example the two sets of guidelines for midwives and obstetricians working with pregnant individuals, or the many different guidelines for the range of healthcare professionals working with older people in care homes.
 
Ethics, empathy and connection
Feelings of compassion (the desire to alleviate suffering) are important for healthcare professionals. In order to cope, and to be able to make decisions, it is important to mix in logic and reason, but this can result in healthcare professionals taking too big a step back, and healthcare becoming too dehumanised. Empathy (feeling what others feel), can play an important role by allowing healthcare professionals to: develop a two-way relationship with patients; gain insight into their condition and mindset; step into their shoes; respect their dignity; and base their care on the understanding gained.

This is a personal as well as a scientific blog, and as such is being posted on both my websites. My BMI currently puts me into the obese category. I have often said that I don't have an issue with food – I just like it too much. I may be fit and obese, running half marathons, but I can still be damaging my joints and my heart, and risking type 2 diabetes. ​But now, in the time of Covid-19, obesity puts me at a higher risk than the rest of the population should I become infected.

How big is the risk?
In patients under 60, obesity is a risk factor for hospital admission. In a US study, patients with a BMI of 30-34 were around twice as likely to be admitted to acute or critical care, compared with those with a BMI of less than 30. In patients with a BMI of over 35, the likelihood of being admitted to acute or critical care rose by 2.2-fold and 3.6-fold, respectively. Higher numbers of obese patients require invasive mechanical ventilation.

The OpenSAFELY collaborative carried out a review of electronic medical records of patients in England. According to the results, having a BMI of between 30 and 35 (obese) increases the risk of hospital death by 1.3-fold. This climbs to 1.6-fold for a BMI of 35-40,  and a BMI of greater than 40 (morbidly obese) more than doubles the risk of death (2.3-fold). Because the science is moving so quickly, this preprint has not yet been finalised or assessed by experts (peer-reviewed).

The science behind the difference
Being overweight generally makes it harder to breathe, and is known to be a risk factor in respiratory diseases such as asthma, sleep apnoea, acute lung injury and acute respiratory distress syndrome.

There are a number of theories behind the increased risk of more severe illness and death related to Covid-19 in people who are obese:

• Obesity is often linked with type 2 diabetes and other metabolic disorders, which are risk factors in Covid-19 infection.
• Excess fat in the body can cause low-grade chronic systemic inflammation, worsening respiratory diseases.
• The fatty tissue may act as a viral reservoir.
• Excess fat is linked with overactivation of the complement system, part of the immune system. This could increase the risk of a cytokine storm, an uncontrolled and dangerous immune system overreaction.

It is also much harder to intubate someone who is obese, and ventilation is more difficult as the lungs are smaller compared with the size of the body and oxygen demand is higher.
Looking at the futureMy weight has gone up and down over the years. My biggest gains were in my thirties, and I lost three stone before I got married in 2009, giving me a BMI of 24. During my marriage and following bereavement, the weight went right back on.
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But it's not just me. The most recent Health Survey for England (2018) found that 67% of men, 60% of women and 28% of children were overweight or obese. As SARS-CoV-2, the virus that causes Covid-19, is likely to stick around for some time to come, tackling obesity is going to be important.

As part of COUCH Health's mission to improve 1 million lives by 2022, I have pledged to lose weight as part of a challenge alongside my friend and medcomms colleague, Ash Rishi. It has been up and down during the lockdown, but I'm going to try again, driven by the excess risk of Covid-19, using the evidence-based and NHS-backed Low Carb Program. 

​Business development teams looking to fill pharma company pipelines are seeking products that meet unmet medical needs, either filling gaps where there are no existing treatments, or creating a product that is significantly better than something already on the market. These opportunities should come with solid science and at least the beginning of a good data package created using studies with the right models and the right controls.

​As discussed in an earlier #CoffeeBuddies session, investments pre-Covid-19 had started to move to earlier stage projects, and this needs companies to reach out actively to universities and biotechs that have assets based on good science that might otherwise slip under the radar. This can be helped by good local, national, and international networks created through links with national and local trade organisations, and local academia. Operating companies in individual territories may be able to provide information on local research via their networks, and even keep an eye open for ideas.
By building relationships with biotechs and academia even before they have something to licence, companies can get an early 'foot in the door'. They can ensure that the science is good as well, by mentoring and supporting the SMEs and institutions as they develop their data packages.

In order to pick the right projects, business development and licensing teams need to remain objective. Working together can help to reduce any natural bias, and can also provide subject matter and technology expertise. Working without a 'shopping list' means that projects can be picked up opportunistically, potentially creating a whole new franchise.

Combatting Covid-19
SARS-CoV-2 is a virus that is potentially fatal, and increasing evidence suggests that it could have longer-term effects for some people. This threat is providing a driver for business development teams to find and partner for generic and innovative drugs that could help. The urgency means that some companies are making announcements at the statement of interest stage, even before full agreements are in place. It will be interesting to see if this remains after the crisis is over.

Before the outbreak, MSD's pipeline already included research key to the area of Covid-19 infection – infectious disease, vaccines, immunology and respiratory disease. After the outbreak, the company switched almost all of its efforts to respond to the Covid-19 outbreak The business development teams, the global competitive intelligence group and the discovery teams have worked together to evaluate around 250 different targets and programs with early stage data packages. Assessment of potential assets is ongoing. This includes screening of existing drugs for new activity, which could potentially speed up drug development.

MSD's response to Covid-19 includes a number of vaccine projects. Deciding which will go forward will depend on further understanding of the immunology of the virus, and the manufacturability, safety and immunogenicity of the different candidate vaccines.

The most appropriate type of vaccine for the prevention of Covid-19 isn't yet clear, and companies around the world are taking a number of different tactics, as a previous #CoffeeBuddies session talked about. These include viral vectored and nucleic acid vaccines, which are still new approaches and may prove challenging for approval and scale-up; inactivated and protein subunit vaccines, which are tried and tested but can be complex to manufacture and often need a booster; and live-attenuated vaccines, which produce a strong immune response but may be associated with risks. Controlling the spread of the SARS-CoV-2 virus may require a lower risk vaccine and boosters to develop herd immunity, along with ring vaccination with a shot that produces a faster response but with a slightly higher risk of side effects.

What will the pandemic mean for investors
While the pandemic is ongoing, companies focusing on Covid-19 prevention and treatment are unlikely to make much of a profit; any marketed drugs, especially vaccines will need to be distributed widely and provided cost-effectively to those at highest risk. This means that long term investment will be needed, with an extended period until return on investment – both companies and shareholders will need to be patient.

The future: the 'new normal?
The biopharma industry is currently very much focused on vaccines, virology, immunology, and infectious diseases, which haven't been 'fashionable' areas of research. However, it's likely that there will be a shift back into 'normal' ways of working, with the focus returning to therapeutic areas with a higher potential return on investment, such as oncology and cardiovascular disease.

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This blog post is based on a conversation between Kat Arney, founder of First Create The Media, Peter Penny, life and career mentor, and the #CommunicationBuddies, a virtual discussion group hosted by Graham Combe and chaired by Professor Tony Sedgwick.
 
Telling stories to each other is a key part of what makes us human. Stories help us make sense of the world, put things in order in our own heads and the heads of our listeners, and aid us in thinking about the form of our lives. Telling stories isn't just personal though – stories play an important role in science and business communication, from explaining concepts to pitching for projects and funding.

The importance of story in comms: Boring comms waste lives
Communicating ideas in story form can stop presentations from being mind-numbing, and become more than just lists of facts or milestones. Boring communications waste lives, by frittering away the listener or reader's precious time. They also allow important ideas that could impact wellbeing, lives and health to slip by unnoticed. The ordered structure of a story not only helps the listener but also works as a cognitive tool to help the teller order their ideas.

Building the story
As in fiction and drama, comms stories have a beginning, a middle and an end. They draw the listeners in and make them want to know what happens next.

Good comms stories use characters – patients, diseases, drugs, researchers – and show what happens to them. They make the listeners feel something and want to do something. Depending on the context, this could be excitement that makes them want to invest, conviction that makes them want to spread the word, or passion that makes them want to campaign and make a difference.

Getting the level of detail right is vital in comms. Too much information swamps the listener and buries the critical bits of information, and too little misses out what is important. The level of detail will vary according to the audience – do they want the Lambs' Tales from Shakespeare, or the story of King Lear? The right number of significant details gives the listeners, be they investors, journalists or healthcare professionals, enough to hold on to, and that might mean cutting favourite facts or slides. The presentation should end leaving people informed and wanting to act.

Preparing the pitch
Pitching is a fundamental part of the communications process, and it's important to be as Olympic fit as Princess Anne was in the London 2012 bid. As an Olympian, she was able to talk from a point of knowledge and experience. She presented what the International Olympic Committee needed to hear; that London was able to meet the needs of the games, and could put the logistics and infrastructure in place.

A pitch must meet the client's needs, deal with any pain points, and be in the style that will be most useful. This could mean a traditional presentation, or a Q&A session. Reviewing the presentation from the client's perspective as well as the presenter's perspective can be useful, perhaps by putting a member of another team in the position of the client. This makes sure that it is written in the client's language, and helps to highlight anything that is missing.

Moving virtual
During the Covid-19 lockdown, meetings and pitches have quickly become virtual. This will continue as long as social distancing is in place, and may even become part of the post-virus 'new normal'. While virtual meetings allow life to continue, they do bring their own challenges. Virtual meetings do feel more 'real' than voice-only calls, but they can be exhausting. Fewer non-verbal cues and body language come across, and those that do can be harder to process, all of which takes more energy.

If virtual meetings are going to become the way forward, all participants need to become comfortable with taking part. There are a number of ways to get the most out of virtual presentations:

• Be comfortable with the software
• Mute participants during presentations
• Put plenty of energy into vocal presentations to make up for lost non-verbal cues
• Be well prepared and know the material
• Speak clearly, as virtual meetings can be hard for people with hearing issues
• Push the camera back to show upper body and hands
• Keep presentations short and simple, focusing on fewer details, and offer the opportunity for follow up
• Practice presentations beforehand

I've been completing the COVID-19 Symptom Study app for some weeks now. This app, developed by King’s College London and health science company ZOE, has been created to combine symptom reports with software algorithms to try to predict who has the virus. This information can then be used to track SARS-CoV-2 infections across the UK and further afield. The study also looks at how symptoms and risks vary between individuals.

I had reported headaches and chills over the weekend, which I think were the result of late nights doing coursework for my MA. The combination triggered an algorithm, inviting me to go for a PCR swab test to help the researchers to understand which symptoms are most related to Covid-19 infection.

"You’ve recently reported feeling unwell with a particular combination of symptoms. We would like to test you to understand if you have the virus right now. This does not necessarily mean you have COVID-19 as we are also inviting some people we believe do not have the virus."

I booked the test through the Department of Health website, which was a bit long-winded but pretty clear, and picked a site for a test, about a 40 minute drive away. I was a bit wary, as I know friends of mine have had bad experiences with the sites, and when I got close to Meadowhall I got a bit anxious, as there were no signs. I followed a stream of traffic, as I figured that SARS-CoV-2 testing was probably the only thing happening at the Meadowhall shopping centre that day, and from that point on it all went really smoothly and efficiently (until I left the site, took the wrong turning and ended up in an industrial estate, but that was my fault, not theirs).

The site was staffed with soldiers in army fatigues and PPE, and as I pulled in, I was shown a sign telling me to keep my window shut unless otherwise told, and to show the QR code I got at registration. I then drove to the next point, where a very pleasant soldier handed me the test using a long-armed grab tool  explained the process to me – I was to drive to a parking bay, swab my throat and then my nose, put the swab in the tube, label the tube lengthways with the bar code, and put it in the bag but not seal it. If I needed help, I should put my hazard lights on.

I did the test as per the instructions, swabbing my tonsils (eww) and then pushing the swab up each nostril as far as I could and turning it (ouch). Not something I plan on doing again unless I must. I drove to the exit, where the soldier at the gate checked the bag contents and then told me to seal it, and then grabbed the bag with a long-armed grabber tool. I then drove to the gate, confidently turned right, turned round in the industrial estate and drove back past the testing site with my best 'I meant to do that' expression on my face.

There are a couple of videos on the Department of health website that I found really useful – visiting a regional test site and How to take a coronavirus self-test swab. The results came by text within 48 hours and were negative, thankfully. I have added the result to the app.

The app has led to some breakthroughs in information on Covid-19:

• Losing the sense of taste or smell is a stronger predictor of infection than fever
• Genetics plays a role in symptom severity
• Infection prevalence and severity is higher in urban areas and areas of higher poverty
• Symptoms differ in older and younger people

The researchers behind the app are also looking into the influence of hormones such as oestrogen in the responses to infection, and, as well as the effect of ACE inhibitors (angiotensin converting enzyme inhibitors) or ARBs (angiotensin receptor blockers) on the chance of infection.